What is sodium tartrate dihydrate used for?

Sodium tartrate dihydrate is the volumetric standard for Karl Fischer titration. Under normal conditions, it is stable and non-hygroscopic. Sodium tartrate dihydrate has a stoichiometric water content of 15.66% and is primarily used for titer determination in volumetry.

Why is sodium tartrate dihydrate moisture standard?

Sodium tartrate dihydrate is a solid standard with water content of 15.66% determined by the technique of loss on drying at 150°C. Its preparation from high-purity reagents and analysis is completed in an ISO/IEC 17025 and ISO 17034 accredited calibration laboratory.

Why we use sodium tartrate in Karl Fischer?

Why we use sodium tartrate in Karl Fischer? The volumetric standard for Karl Fischer titration is sodium tartrate dihydrate. It is stable and non-hygroscopic, under normal conditions. Sodium tartrate dihydrate has a 15.66 percent stoichiometric water content and is primarily used in volumetry to measure the titer.

Is sodium tartrate soluble in water?

Sodium tartrate (Na2C4H4O6) is a salt used as an emulsifier and a binding agent in food products such as jellies, margarine, and sausage casings. As a food additive, it is known by the E number E335.

Sodium tartrate.

Solubility in water soluble
Solubility insoluble in ethanol
ATC code A06AD21 (WHO)

What is the purpose of tartrate?

The main forms of tartrates used commercially are pure crystalline tartaric acid used as an acidulant in non-alcoholic drinks and foods, cream of tartar used in baking, and Rochelle salt, commonly used in electroplating solutions.

Is sodium tartrate hazardous?

Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. May be harmful if inhaled.

Why DST is used for KF calibration?

DST (disodium tartrate) is used as a primary standard in the Karl Fischer titration because it easily reacts with the KF reagent and it has a highly stable crystalline structure.

What does too much moisture indicate in certain pharmaceutical preparations?

The presence of moisture affects the consistency and stability of tablets. Too much moisture will cause an agglomeration of powder particles and a poor crumbly tablet; too little moisture will cause the tablet to fall apart.

What is the range of KF factor?

Thus, the optimal pH range for the Karl Fischer reaction is from 5 to 8, and highly acidic or basic samples need to be buffered to bring the overall pH into that range.

Why only methanol is used in KF titration?

According to KF principal is medium should be need lower alcohol or organic solvent and lower alcohol is methanol. The iodine react with water, the consumed iodine value is water content. All drugs are polar nature so easily dissolve in methanol so used to neutralized kf reagent.

Is tartrate water soluble?

Potassium tartrate is a colorless crystal or white crystalline powder soluble in water.

How do you make sodium tartrate buffer?

So if you prepare a 0.1 mol/L of Tartaric acid abd a 0.1 mol/L of sodium potassium tartrate and mix them together in equal volumes the pH of the resulting solution will be 2.9 and you can adjust the pH to 3.0 if required by the addition of drop by drop of conc HCL or more 0.1 mol/L of Tartaric acid.

Is sodium tartrate baking powder?

Baking Powder – It is a dry chemical leavening agent, a mixture of a carbonate or bicarbonate, and a weak acid. These baking acids are tartrate, phosphate, and sodium aluminum sulfate used alone or in combination. It contains sodium bicarbonate. It is used to increase the volume and lighten the texture of baked goods.

What is tartrate mean?

Definition of tartrate

: a salt or ester of tartaric acid.

Why Methanol is used in KF titration?

Methanol is typically used as the working medium in the titration cell. One-component volumetric reagents are easier to handle, and are usually less expensive than two-component reagents.

How does moisture affect drug stability?

What is the limit of moisture content?

Generally 1 – 2.5% based on IPC methods (e.g. mettler moisture content analyzer).

What is water content by KF?

KF has a high accuracy and precision, typically within 1% of available water, e.g. 3.00% appears as 2.97–3.03%. Although KF is a destructive analysis, the sample quantity is small and is typically limited by the accuracy of weighing.

Why is DST used in KF calibration?

Answer. Sodium tartrate dihydrate is the volumetric standard for Karl Fischer titration. Under normal conditions, it is stable and non-hygroscopic. Sodium tartrate dihydrate has a stoichiometric water content of 15.66% and is primarily used for titer determination in volumetry.

Why KF reagent is pyridine-free?

The pyridine-free Karl Fischer reagent consists of two solutions, a dissolving agent and a titrating agent. The dissolving agent contains sulfur dioxide and a pyridine substitute in a solvent and is used for taking up the sample to be investigated with respect to its water content.

What is the function of tartrate?

How will you prepare a buffer solution?

Methods to Prepare Buffer Solutions
Add water to make up to 1 L. Add water to make up to 1 L. (Alternatively, dilute 100 mM phosphoric acid (sodium) buffer solution (pH=2.1) ten times.) Add water to make up to 1 L.

How do you prepare a buffer solution for pH meter calibration?

5.3 Take 100 ml buffer pH 4.0 & pH 7.0 from the Certified buffer bottle in a glass bottle. Discard the Standard pH buffer after one month. Dissolve 10.12 gm. of KHC8H4O4 ( previously dried at 110 oC for 1 hour) in water to make 1000 ml.

What is the difference between baking powder and baking soda?

Baking soda is pure sodium bicarbonate, whereas baking powder also contains an acid, such as cream of tartar, and cornstarch. Baking soda is a raising agent that contains one or more acid ingredients, such as cocoa powder or buttermilk. Baking powder is better for recipes that contain little or no acid ingredients.

Is baking powder and baking soda the same?

Baking soda and baking powder are not the same. Sodium bicarbonate and bicarbonate of soda are other names for baking soda. Baking powder is made of baking soda plus cream of tartar and cornstarch. Baking powder can be substituted for baking soda by tripling the amount of baking powder.