How do you administer a Cubicin?

CUBICIN should be administered intravenously either by injection over a two (2) minute period or by infusion over a thirty (30) minute period. CUBICIN 4 mg/kg should be administered intravenously in 0.9% sodium chloride injection once every 24 hours for 7 to 14 days.

How do you mix Cubicin?

Ensure that all of the CUBICIN powder is wetted by gently rotating the vial. Allow the wetted product to stand undisturbed for 10 minutes. Gently rotate or swirl the vial contents for a few minutes, as needed, to obtain a completely reconstituted solution.

How can daptomycin be administered?

In adults, Daptomycin is given by intravenous infusion (see section 6.6) and administered over a 30-minute period or by intravenous injection (see section 6.6) and administered over a 2-minute period.

Why daptomycin is given once daily?

Daptomycin should be administered intravenously once daily, because adverse effects on skeletal muscle associated with an increase in plasma levels of creatine phosphokinase and myopathy were observed more frequently at shorter dosing intervals.

Does Cubicin need to be refrigerated?

Discard unused portions of CUBICIN. Stability studies have shown that the reconstituted solution is stable in the vial for 12 hours at room temperature and up to 48 hours if stored under refrigeration at 2 to 8°C (36 to 46°F).

Does daptomycin need peak and trough?

Daptomycin is bactericidal against Gram-positive bacteria, with peak-dependent effect but trough-dependent toxicity.

How do you reconstitute a Cubicin?

Ensure that all CUBICIN powder is wetted by gently rotating the vial. Allow the wetted product to stand undisturbed for 10 minutes. Gently rotate or swirl the vial contents for a few minutes, as needed, to obtain a completely reconstituted solution.

Is Cubicin and daptomycin the same thing?

Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms.

What should be monitored when taking daptomycin?

Patients should be monitored for CPK levels and, in those with renal impairment, renal function, at least once per week and should consider temporarily suspending the use of HMG-CoA reductase inhibitors. Daptomycin should not be administered more than once per day.

What should I monitor with daptomycin?

Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly.

How long can daptomycin vial be out of the fridge?

The combined storage time (reconstituted solution in vial and diluted solution in infusion bag) should not exceed 12 hours at room temperature or 48 hours under refrigeration.

What is Cubicin used for?

This medication is an antibiotic used to treat serious bacterial infections. It works by stopping the growth of bacteria. This medication is not recommended for use in children younger than 12 months due to possible risk of serious side effects.

Is daptomycin compatible with normal saline?

Our results suggest that daptomycin reconstituted vials (50 mg/mL in normal saline) and infusion solutions (5.6 and 14 mg/mL in normal saline) are physicochemically stable over a period of at least 1 week at 2–8°C.

How do you know if daptomycin is working?

Your doctor will check your progress closely while you are receiving daptomycin. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

When should you not take daptomycin?


  1. Clinical Consideration. Daptomycin is contraindicated in patients with a known hypersensitivity reaction to the drug or any component within the formulation.
  2. Geriatric Patients.
  3. Pregnancy.
  4. Breastfeeding.
  5. Renal Impairment.
  6. Bacterial Resistance.
  7. Drug Interactions.

Is daptomycin hard on the kidneys?

This medicine may cause serious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS), which can damage organs, including the liver, kidney, or heart.

Is daptomycin a high risk medication?

Do you refrigerate daptomycin?

Store daptomycin in the refrigerator. Do not freeze. After mixing daptomycin with a diluent, store in the refrigerator and use it within 48 hours. You may also store mixed daptomycin for up to 12 hours at room temperature.

What should I monitor on daptomycin?

What are the most common side effects of daptomycin?

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site.
  • difficulty having a bowel movement.

What should be monitored while on daptomycin?

Is daptomycin stronger than vancomycin?

Conclusions: The results demonstrated that daptomycin was associated with a better outcome compared with vancomycin for the treatment of BSIs due to MRSA with higher vancomycin MICs.