Can daptomycin treat endocarditis?

Currently, daptomycin is FDA-approved at a dose of 6 mg/kg/day for the treatment of S. aureus bacteremia and associated right-sided endocarditis. However, numerous in vitro and clinical studies suggest that daptomycin doses up to 12 mg/kg/day may provide improved efficacy and resistance prevention.

What is the side effects of daptomycin?

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site.
  • difficulty having a bowel movement.

What should be monitored when taking daptomycin?

Patients should also receive monitoring for muscle pain or weakness, new-onset or worsening peripheral neuropathy, and signs or symptoms of eosinophilic pneumonia. [14][18] Furthermore, patients who develop diarrhea should have testing for C. difficile infection.

Why is daptomycin inappropriate to treat MRSA PNA?

For the treatment of MRSA-related lung infections, including pneumonia, daptomycin is not recommended because it is inactivated by the lung surfactant (7).

Who should not take daptomycin?

This medication is not recommended for use in children younger than 12 months due to possible risk of serious side effects.

When should daptomycin be discontinued?

Daptomycin should be discontinued in patients with symptoms of muscle pain or weakness whose CPK levels exceed 1000 U/L (~ 5x ULN), or in patients without symptoms whose CPK exceeds 10x ULN.

Is daptomycin stronger than vancomycin?

The hypothesis of our trial is that daptomycin treatment is superior to vancomycin treatment in reducing the 60-day all-cause mortality rate from BSIs due to MRSA with high vancomycin MICs from 25 to 10%.

What bacteria is resistant to daptomycin?

Although daptomycin resistance in Gram-positive bacteria is uncommon, there are increasing reports of daptomycin resistance in Staphylococcus aureus, Enterococcus faecium and Enterococcus faecalis.

When can you not use daptomycin?

You should not use daptomycin if you are allergic to it. Tell your doctor if you have ever had: kidney disease; or. a nerve or muscle disorder.

Is daptomycin a high risk medication?

This medicine may cause serious allergic reactions, including anaphylaxis. This can be life-threatening and requires immediate medical attention.

How long can you take daptomycin?

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Age Group Indication
Dosage Regimen Duration of Therapy
12 to 17 years 5 mg/kg once every 24 hours infused over 30 minutes Up to 14 Days
7 to 11 years 7 mg/kg once every 24 hours infused over 30 minutes
2 to 6 years 9 mg/kg once every 24 hours infused over 60 minutes

Is daptomycin hard on the kidneys?

Statistical analysis. In a previous study [17], the incidence of renal dysfunction was estimated at 12% with daptomycin and 35% with standard therapy. However, a higher incidence of renal failure was expected in ICU population, as much as twice the incidence observed in the reference study [10, 19].

Is daptomycin the same as vancomycin?

Daptomycin, a lipopeptide antibiotic, is approved by the US Food and Drug Administration for the treatment of S. aureus bacteremia and is considered a reasonable alternative to vancomycin. The efficacy of daptomycin has been demonstrated in an open-label randomized clinical trial by Fowler et al.

Why is daptomycin restricted?

The Antimicrobial Restrictions are in place due to concerns regarding a variety of issues: off-label use; the need for increased dosage for patients with bacteremia/endocarditis or other serious infections due to gram-positive pathogens; contraindication for daptomycin use in patients with pneumonia.

What infection is daptomycin used for?

Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream (bacteremia), including right-sided infective endocarditis. Daptomycin belongs to the class of medicines known as antibiotics.

Which is stronger daptomycin or vancomycin?

What class of antibiotics is daptomycin?

Daptomycin injection is in a class of medications called cyclic lipopeptide antibiotics. It works by killing bacteria.

How long should I take daptomycin?