How serious is transitional cell carcinoma?

Transitional Cell Carcinoma: An Aggressive Cancer

Transitional cell carcinoma affects the transitional cells of the urinary system and accounts for an overwhelming majority of bladder cancer diagnoses. This cancer may spread rapidly, affecting other organs and becoming life-threatening in some cases.

How long do you live with transitional cell carcinoma?

The median overall survival (OS) was 46 months, and the 5-year OS rate was 41.8%. The median cancer-specific survival (CSS) was 78 months, and the 5-year CSS rate was 54.3%.

What is renal transitional cell carcinoma?

Renal transitional cell carcinoma (TCC), or renal urothelial carcinoma (UC), is a malignant tumor arising from the transitional (urothelial) epithelial cells that line the urinary tract from the renal calyces to the ureteral orifice (see the image below). UC is the most common tumor of the renal pelvis.

Can transitional cell carcinoma be cured?

Transitional cell carcinoma of the renal pelvis, accounting for only 7% of all kidney tumors, and transitional cell cancer of the ureter, accounting for only 1 of every 25 upper urinary tract tumors, are curable in more than 90% of patients if they are superficial and confined to the renal pelvis or ureter.

What is the treatment for transitional cell carcinoma?

Current treatments for transitional cell carcinoma include: Endoscopic resection, fulguration, or laser surgery. Through a ureteroscope, physicians can destroy or remove cancer cells with direct tumor removal, electrical current, or laser.

Is renal pelvis curable?

It’s helpful to get an early diagnosis of transitional cell cancer of the renal pelvis and ureter, because the disease is highly curable when it’s treated before it spreads.

What is the best treatment for transitional cell carcinoma?

Most cases of TCC in the renal pelvis and ureter can be cured if they’re found and diagnosed early enough. Surgery is the standard treatment for this type of cancer. If you need surgery, you may require a nephroureterectomy.

What is the main cause of transitional cell carcinoma?

Risk factors for transitional cell cancer of the renal pelvis and ureter include the following: Having a personal history of bladder cancer. Smoking cigarettes. Taking a lot of certain pain medicines, such as phenacetin.

Where does TCC spread to first?

TCC of the kidney starts in the part of the kidney called the renal pelvisrenal pelvisThe renal pelvis or pelvis of the kidney is the funnel-like dilated part of the ureter in the kidney. In humans, the renal pelvis is the point where the two or three major calyces join. › wiki › Renal_pelvisRenal pelvis – Wikipedia. TCC can also start in the ureters, bladder and urethra.

What is the primary symptom of transitional cell carcinoma?

Symptoms. The symptoms of transitional cell cancer of the kidney are similar to those of other types of kidney cancer. They include blood in the urine and pain in your back, between the lower ribs, and the top of your hip bone. You may also need to pass urine very often or have pain when passing urine.

How do you treat renal pelvis?

The goal of treatment is to eliminate the cancer. The following procedures may be used to treat the condition: Nephroureterectomy — This involves removal of entire kidney, ureter, and the bladder cuff (tissue that connects ureter to the bladder) Nephrectomy — Surgery to remove all or part of the kidney is often done.

The 5-year survival rate in selected patients after conservative surgery is reported to be 70-90%. Recurrences in the remaining urothelium after conservative treatment are relatively frequent because of the multifocal nature of TCCs. Ipsilateral recurrence rates may reach 25-50%.

Can you survive transitional cell carcinoma?

The prognosis for any patient with metastatic or recurrent transitional cell cancer is poor. The proper management of recurrence depends on the sites of recurrence, extent of prior therapy, and individual patient considerations.

What is the survival rate of urothelial carcinoma?

Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time (usually 5 years) after they were diagnosed.

5-year relative survival rates for bladder cancer.

SEER Stage 5-year Relative Survival Rate
All SEER stages combined 77%

Surgery is the most common treatment for transitional cell cancer of the kidney. This is usually a major operation, so you need to be fit enough to make a good recovery. Depending on the stage and grade of the cancer you may have chemotherapy after surgery, or (rarely) radiotherapy.

How aggressive is urothelial carcinoma?

Muscle-invasive urothelial carcinomas are highly aggressive compared to cancers of the upper urinary tract, carrying a five-year disease-specific survival rate of <50% in pT2/pT3 disease, and this survival rate drops below 10% in pT4 cancer.

Can urothelial carcinoma be cured?

The prognosis depends on the following: The stage of the cancer (whether it is superficial or invasive bladder cancer, and whether it has spread to other places in the body). Bladder cancer in the early stages can often be cured.

What is the treatment for urothelial cell carcinoma?

Systemic chemotherapy is the standard approach for the initial treatment of patients with inoperable locally advanced or metastatic urothelial malignancies. Although initial response rates are high, the median survival with multiagent chemotherapy is approximately 15 months [1,2].